Biodegradable Synthetic Small-calibre Vascular Grafts: 1-Year Results after Replacement of the Rat Aorta
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چکیده
Galway, Ireland Biodegradable Synthetic Small-calibre Vascular Grafts: 1-Year Results after Replacement of the Rat Aorta Beat H. Walpoth, Damiano Mugnai, Jean-Christophe Tille, Francesco Innocente, Benjamin Nottelet, Corinne Berthonneche, Xavier Montet, Sarra de Valence, Wojciech Mrowczynski, Afksendiyos Kalangos, Robert Gurny, Michael Moeller Corresponding author: [email protected] Dept. of Cardiovascular Surgery, University Hospital of Geneva , Geneva, Switzerland, Dept. of Pathology, University Hospital of Geneva, Geneva, Switzerland, Dept. of Pharmaceutics & Biopharmaceutics EPGL, University of Geneva, Geneva, Switzerland, Dept. of Medicine, University Hospital of Lausanne, Lausanne, Switzerland, Dept. of Radiology, University Hospital of Geneva, Geneva, Switzerland.
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Vascular Endothelial Growth Factor Improves Physico-Mechanical Properties and Enhances Endothelialization of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/Poly(ε-caprolactone) Small-Diameter Vascular Grafts In vivo
The combination of a natural polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and a synthetic hydrophobic polymer poly(ε-caprolactone) (PCL) is promising for the preparation of biodegradable and biocompatible small-diameter vascular grafts for bypass surgery. However, physico-mechanical properties and endothelialization rate of PHBV/PCL grafts are poor. We suggested that incorporatio...
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